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非注射给药重组人胰岛素的制备及应用

成果领域: 精准医疗

推广方式:

成果归属企业: 吉林大学公共卫生学院刘晋宇教授科研团队

成果鉴定时间:

成果介绍

糖尿病是由于胰岛素分泌不足或胰岛素抵抗所引起的、以血糖升高为主要特征，伴有糖、蛋白质和脂肪代谢紊乱，导致多种器官损害的代谢性疾病。糖尿病已成为严重危害我国居民健康的重大疾病。在充分调研国内外胰岛素制备技术基础上，采用基因工程技术，结合细胞生物学理论，历经近10年时间，制备出全新的重组人胰岛素融合蛋白。该胰岛素融合蛋白在不需要任何佐剂的帮助下，经过皮肤或口腔粘膜给药后，直接穿过生物膜屏障，进入细胞，在细胞中蛋白酶作用下，形成成熟胰岛素，并从细胞中释放入血，逆转糖尿病高血糖。

成果应用案例介绍

联系方式

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