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一种针对多粘菌素耐药菌特异性治疗候选辅助药物

成果领域: 现代农业

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成果归属企业: 吉林大学汽车动物医学学院邓旭明教授科研团队

成果鉴定时间:

成果介绍

针对全世界范围广泛流行的mcr-1及携带菌的多粘菌素耐药性问题，进行长期和大量的天然化合物抑制剂筛选，发现以MR1033为代表的多种化合物可恢复多粘菌素对不同来源携带mcr-1大肠杆菌的敏感性，协同作用明显（FIC index=O.156-0.188）。在小鼠腹腔感染和肺部感染模型中显著提高多粘菌素B的治疗率。

成果应用案例介绍

联系方式

电话/微信: 13822630888

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基本文件流程错误 SQL 调试

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[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000012s ]
[ CACHE ] INIT File
[ BEHAVIOR ] Run \addons\briefurl\Briefurl @app_init [ RunTime:0.001280s ]
[ BEHAVIOR ] Run \addons\fastflow\Fastflow @app_init [ RunTime:0.000026s ]
[ BEHAVIOR ] Run \addons\notice\Notice @app_init [ RunTime:0.000244s ]
[ BEHAVIOR ] Run \addons\qrcode\Qrcode @app_init [ RunTime:0.000202s ]
[ BEHAVIOR ] Run \addons\treaty\Treaty @app_init [ RunTime:0.000029s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @app_init [ RunTime:0.000015s ]
[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000031s ]
[ BEHAVIOR ] Run app\common\behavior\Common @app_init [ RunTime:0.000227s ]
[ LANG ] /www/wwwroot/open.juabc.com/thinkphp/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @app_dispatch [ RunTime:0.000010s ]
[ ROUTE ] array ( 'type' => 'module', 'module' => array ( 0 => 'index', 1 => 'results', 2 => 'views', ), )
[ HEADER ] array ( 'accept-encoding' => 'gzip, br, zstd, deflate', 'user-agent' => 'Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)', 'accept' => '*/*', 'host' => 'open.juabc.com', 'content-type' => '', 'content-length' => '', )
[ PARAM ] array ( 'ids' => '4551', )
[ LANG ] /www/wwwroot/open.juabc.com/public/../application/index/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @module_init [ RunTime:0.000700s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @module_init [ RunTime:0.000114s ]
[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @module_init [ RunTime:0.000017s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @upload_config_init [ RunTime:0.000368s ]
[ BEHAVIOR ] Run \addons\editpage\Editpage @config_init [ RunTime:0.000031s ]
[ BEHAVIOR ] Run \addons\notice\Notice @config_init [ RunTime:0.000022s ]
[ DB ] INIT mysql
[ BEHAVIOR ] Run \addons\csmtable\Csmtable @action_begin [ RunTime:0.000024s ]
[ RUN ] app\index\controller\Results->views[ /www/wwwroot/open.juabc.com/application/index/controller/Results.php ]
[ VIEW ] /www/wwwroot/open.juabc.com/public/../application/index/view/results/views.html [ array ( 0 => 'user', 1 => 'site', 2 => 'config', 3 => 'data', 4 => 'active', 5 => 'login', 6 => 'catelist', 7 => 'views', ) ]
[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @view_filter [ RunTime:0.000029s ]

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